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Fig. 9. cADPR increased the rate of Ca2+ removal following depolarization and inferred plasma membrane Ca2+ pump activity. (A) Dialysing the cell with free cADPR (300 µM; Ab,c) increased the rate of [Ca2+]c decline following depolarization (–70 mV to +10 mV) compared with controls [Aa,c; n=40 (control), n=17 (free cADPR)]. (B) The effects of cADPR on the sarcolemma Ca2+ pump. The sarcolemma Ca2+ pump activity was obtained by inhibiting removal occurring via mitochondria, SR and Na+-Ca2+ exchange. By subtracting from the rates of decline in cADPR, the rates in control (minus those occurring when removal by mitochondria, SR and Na+-Ca2+ exchange were inhibited), an inferred Ca2+ pump rate was obtained. This was increased by cADPR (*P<0.05; **P<0.01).





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