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Fig. 3. Depolarisation but not cADPR contracted single colonic myocytes. Photolysed cADPR ({uparrow} 50 µM) failed to increase F/F0 (C) or to contract colonic myocytes [P>0.05 (Di)]. Depolarisation to +10 mV [holding potential –70 mV (A)] induced an inward ICa (B and expanded timescale inset) and a Ca2+ transient (C). Following the increase in [Ca2+]c (F/F0), (Dii) shows the mean changes in cell length produced by depolarization (P<0.05) and (Di) the failure of cADPR to induce contraction (n=10-18, P>0.05). Alignment of time with the videotaped contractile behaviour of the cell (E) was achieved by cell illumination with a flash lamp (Ei) or an LED triggered by depolarisation (Eii).





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