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Fig. 4. cADPR did not increase the amplitude of depolarization-evoked Ca2+ transients. Depolarization (–70 to 0 mV, Aii,Bii,Cii) evoked Ca2+ transients; their amplitudes (expressed in F/F0 units) were not significantly affected by cADPR ({downarrow}; 50 µM, Ai, Bi, Ci) at various time intervals (A, 2 seconds; B, 5 seconds; C, 10 seconds) beforehand; that is, cADPR did not cause CICR following Ca2+ influx.





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