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Fig. 1. Alternative models of Bcl-2 family interactions. Left, anti-apoptotic Bcl-2 family members bind multi-domain pro-apoptotic family members (e.g. Bax), preventing them from inducing cytochrome c release. BH3-only proteins relieve this inhibition, freeing the multi-domain pro-apoptotic family members. Right, anti-apoptotic Bcl-2 family members bind to BH3-only proteins, thus preventing them from inducing Bax activity and cytochrome c release.





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