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Fig. 1. Organization of dynein and dynactin, and their interaction with a microtubule and another cellular organelle. (A) Dynein organization, showing (for simplicity) only two molecules of DIC, DLIC and DLC (B) Dynactin organization. (C) Model for interaction of dynein/dynactin with a microtubule and cellular structure (Karki and Holzbaur, 1995; Holleran et al., 1996). For simplicity, only DHC, DIC, p150Glued, p50 and Arp1 are shown. Dynactin interacts with dynein via association of a middle portion of p150Glued with DIC. Dynein interacts with a microtubule at the tip of the stalk of DHC, whereas dynactin interacts with the microtubule at an N-terminal globular domain of p150Glued. Dynein/dynactin interacts with a cellular structure via an Arp1 filament. Arrow indicates the direction of dynein/dynactin movement. The minus (–) and plus (+) ends of the microtubule are indicated.





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