Fig. 6. Effect of a lithogenic diet on keratin expression levels in the gallbladder and liver. (A) Total tissue homogenates of gallbladders (GB) from K8^–/–, K8^+/– and K8^+/+ mice that were fed a normal or lithogenic diet were analyzed by immunoblotting using antibodies to the indicated keratins and to actin. (B) Total tissue homogenates of livers from the same mice used in A were analyzed by immunoblotting using antibodies to actin, tubulin and the indicated keratins. Note that the LD induces overexpression of keratins in WT mouse gallbladder but not liver.

Return to article