Fig. 4. Kinases involved in LFA-1-mediated migration. Signalling through LFA-1 results in major changes in the T-cell morphology leading to migration. There are two compartments of myosin motor activity. At the leading edge, T-cell attachment and lamellipodial extension is dependent upon myosin, which is activated by MLCK. At the rear of the cell, myosin activated by RhoA and ROCK results in detachment of the trailing edge. The association of PKCßI with microtubules promotes T-cell migration (see text for details and references).

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