Fig. 1. Amino acid sequence alignment of the T. marmorata and mouse a1 isoforms of the V-ATPase a subunit. The T. marmorata sequence obtained in the present report was compared with the sequences of two splice variants (a1-I and a1-II) of the mouse a1 isoform of the V-ATPase a subunit (Nishi and Forgac, 2000). Identical residues are shaded in grey. The nine putative transmembrane domains assigned in the yeast homologue Vph1 (Leng et al., 1999) are shown with a dark bar (I to IX). Conserved residues whose mutation affects the activity or assembly of yeast V-ATPase are in black (Leng et al., 1998).

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