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Fig. 7. Synapses are partially depleted of synaptic vesicles in fat-3 mutant animals. Electron micrographs of wild-type (A) and fat-3(lg8101) (B) synapses fixed by fast-freezing. (A) Clusters of vesicles (ves and arrowheads) in ventral nerve cord neurons are localized close or docked to the active zone (white arrows). (B) Ventral ganglion synapses are depleted of most vesicles close to the active zone (black arrows). A few vesicles lie at a distance (ves and arrowheads). (C) Quantification of synaptic vesicles in fat-3(lg8101)/fat-3(qa1811) mutant animals. The average fraction of synaptic vesicles per section at given distances in fat-3 mutants compared to wild-type animals (100%). Vesicles were considered docked when they were touching the active zone. Total number of synapses scored: 50, fat-3; 42, wild-type. *P<0.001; **P<0.0001. Scale bar: 0.5 µm.





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