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Files in this Data Supplement:
Movie 1. Diffusion and retrograde movement of mGluR5. A 1 mm diameter latex bead has been coupled to mGluR5 by being held in contact with the membrane of a transfected fibroblast lamellipodium. After release of the tweezers, the bead, and thus the underlying receptors, is freely diffusing. After 20±7 seconds on average, the movement shifts from free Brownian diffusion to retrograde directed movement towards the cell body (situated at the bottom). This irreversible transition (depicted by the yellow cross in the video) is interpreted as an anchorage to the retrograde actin flux. DIC images have been acquired on an intensified camera at video rate (25 image/second).
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