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Fig. 5. Mapping of the MegBP-binding site on the megalin tail. Truncations of the human megalin tail sequence were PCR-cloned as bait and tested for interaction with MegBP in the yeast two-hybrid system. The extension of various receptor tail fragments (NM_004525) and their interaction with MegBP are indicated. For clarity, the localization of NPxY, (S/T)xY and PxxP elements in the receptor tail are shown.





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