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Fig. 11. NuMA and lamins are not degraded in MCF-7 cells during
staurosporine-induced apoptosis. Cells grown on a monolayer were untreated
(lane 1) or treated (lane 2) with 2 µM staurosporine for 12 hours and
prepared for SDS-PAGE. Identically loaded gels were run and immunoblotted with
NuMA, lamin A/C, lamin B, PARP-1, caspase-8 or caspase-7 antibody. Note the
partial cleavage of PARP-1, procaspase-8 and disappearance of pro-caspase-7 in
staurosporine-treated cells. NuMA and lamins are not cleaved during the
apoptosis.
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