Fig. 11. Involvement of microtubules in Golgi and MTOC polarity establishment in wound-edge NIH 3T3 cells. (A) Summary of results obtained in this study: the effect on Golgi polarization, MTOC polarization and cell migration of different drugs (nocodazole, taxol, cytochalasin D, Y27632, ST638) and/or different expression constructs (WASP family WCA, several deletion constructs of mDia1 and IRSp53). (B) Proteins involved in MTOC polarity, Golgi polarity and/or cell motility. (C) Rho, ROCK, mDia, IRSp53 and Src proteins are shown inside rectangles, and distributed as shown on the basis of the pathway proposed and described in the literature. It is shown at which level of the pathway and which proteins are important for MTOC polarity, for Golgi polarity and for cell motility.

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