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Centriolar satellites go into orbit

Centriolar satellites are electron-dense granules that surround centrosomes. They have been shown to contain the protein PCM-1 and move along microtubules towards their minus ends (i.e. towards centrosomes). Given their intimate spatial relationship with centrosomes, the satellites could play an important role in centrosome function, but little hard evidence supports this idea. Akiharu Kubo and Shoichiro Tsukita now report the surprising finding that centriolar satellites roam further afield (see p. 919). Using immunofluorescence microscopy, they show that the PCM-1-containing satellites are actually scattered throughout the cytoplasm in numerous cell types. They also provide evidence that satellite formation is cell cycle regulated in vivo, showing that the granules disassemble at mitosis and reassemble in interphase. The authors demonstrate that this depends on regulation of PCM-1 self-aggregation and define the regions of PCM-1 responsible. In addition, they observe that the satellites can associate with -tubulin and cytoplasmic granules that contain the pericentriolar protein pericentrin. One possibility is that the two types of granule interact dynamically while transporting centrosomal proteins to the centrosome; they might also regulate microtubule nucleation by sequestering such proteins away from centrosomes.

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Related articles in JCS:

Non-membranous granular organelle consisting of PCM-1: subcellular distribution and cell-cycle-dependent assembly/disassembly

Akiharu Kubo and Shoichiro Tsukita
JCS 2003 116: 919-928. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?