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Fig. 5. Immunofluorescent images of desmoplakin and cadherin double-stained control and CKO hearts. Shown are stacked confocal images through the intercalated discs in en-face orientation (arrows) in mouse heart sections double stained for desmoplakin (A, control; D, CKO) and cadherin (B, control; E, CKO). Merged images (C, control; F, CKO) suggest that desmoplakin and cadherin are juxtaposed, but in general not co-localized, at the intercalated discs, in a similar pattern in both control and CKO hearts. Magnification, 63x; zoom, 2.96; bar, 10 µm.





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