Fig. 1. Mouse PINS belongs to a highly conserved protein family. (A) The deduced amino acid sequence of mouse Pins derived from a 3.3 kb nucleotide sequence is shown (GenBank accession number AY081187). The seven TPR are in red and the four GoLoco motifs are in green. (B) The degree of amino acid identity between PINS and other homologues. The TPR and GoLoco repeats are highlighted. PINS shares 92% identity with human LGN, 60% identity with rat AGS3, 49% identity with fly Pins and 45% identity with worm PINS.

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