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Fig. 8. Effect of cytochalasin D and A23187 on mean square displacement (MSD) vs. time of endogenous VE-cadherin molecules during their trans-interaction with Cy3-F(ab)-labelled VE-cadherin-Fc. The initial slopes allow determination of the diffusion coefficient D{approx}0.017 µm2/second (untreated cells), 0.17 µm2/second (cytochalasin D) and 0.35 µm2/second (A23187). The saturation value of the MSD allows determination of the barrier free areas to be BFA{approx}0.045 µm2 (untreated), 0.18 µm2 (cytochalasin D) and 0.37 µm2 (A23187). Typical trajectories of individual cadherin molecules in A23187-treated and untreated cells are shown on the right.





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