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Fig. 3. Surface expression of nicastrin is disturbed in PS-deficient cells.
Wild-type (WT) and PS1–/–PS2–/–
MEFs (KO) were surface biotinylated. Biotinylated proteins were precipitated
using streptavidin beads and immunoblotted with B59.2 (
-nicastrin).
Western blot analysis of total cell extracts is shown as a control. Note that
only in WT MEFs is mature nicastrin labeled.
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