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Fig. 8. The role of myosin Va in the transport of secretory granules. (A) After MT-dependent delivery from the TGN to the actin cortex, SGs (green spheres) are captured and removed from the cortical entry site by SG-bound active myosin Va (black circles) via transport along actin fibers as indicated by arrows. (B) The expression of the tail fragment of myosin Va (white semi-circles) blocks myosin Va-mediated capturing and transport of SGs in the actin cortex. This leads to a loss in cortical distribution and formation of clusters of SGs at the interface of the MT- and actin-networks.





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