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Mobile IP₃ receptors

Inositol 1,4,5-trisphosphate receptors (IP₃Rs) are channels that release Ca²⁺ from internal stores following agonist-stimulated generation of IP₃ by phospholipase C. The Ca²⁺ signal generated can take the form of a variety of complex waves/oscillations, and the intracellular distribution of IP₃Rs is thought to influence its spatial and temporal dynamics. Jan Parys and co-workers now reveal that things are even more complicated (see p. 1269). They have examined the subcellular positioning of IP₃Rs in vascular smooth muscle cells stimulated by the hormone arginine-vasopressin. The authors find that, prior to stimulation, IP₃R1 and the SERCA-type Ca²⁺ pump that refills the stores reside in the perinuclear region. After prolonged stimulation, however, they relocalize to the cytoplasm. Parys and co-workers demonstrate that this relocalization can be blocked by agents that inhibit microtubule dynamics or vesicle trafficking. They also show that it depends on protein kinase C (PKC) and that PKC induces outgrowth of microtubules from the perinuclear region into the cytoplasm. The hormone might therefore stimulate PKC-dependent vesicular transport of Ca²⁺-store components from the perinuclear region to the cytoplasmic ER as some form of adaptive response.

Related articles in JCS:

Microtubule-dependent redistribution of the type-1 inositol 1,4,5-trisphosphate receptor in A7r5 smooth muscle cells

Elke Vermassen, Kristel Van Acker, Wim G. Annaert, Bernard Himpens, Geert Callewaert, Ludwig Missiaen, Humbert De Smedt, and Jan B. Parys
JCS 2003 116: 1269-1277. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content