Fig. 3. Myofibrillogenesis in N-cadherin-null myocytes. Wild-type (A,B) and mutant (C,D) myocytes were double stained for F-actin (A,C) and sarcomeric -actinin (B,D). Overall, myofibril structure appeared remarkably similar in these well-spread myocytes, as illustrated by the striated pattern of the myofibril components. Based on the phalloidin stain, it did appear that the mutant myofibrils were somewhat thicker or denser compared with the wild-type structures; however, no apparent difference was observed with -actinin staining. Bar, 50 µm.

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