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Anatomy of the ribosome

Solving the ribosome's crystal structure was a major advance in molecular biology. The fact that many antibiotics target the translational machinery made it all the more important: understanding how these antimicrobial agents function should help us to design new antibiotics, for which there is an increasing need. In Cell Science at a Glance on p. 1391, Jörg Harms and co-workers provide a glimpse of how far we have come. Their poster shows the structures of both ribosomal subunits, the binding sites for different antibiotics and the points at which these act during protein synthesis.

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Antibiotics acting on the translational machinery

Jörg M. Harms, Heike Bartels, Frank Schlünzen, and Ada Yonath
JCS 2003 116: 1391-1393. [Full Text]  

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