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Fig. 3. Proliferation potential of BMSSC clones. A total of 35 CFU-F colonies derived from STRO-1BRIGHT/VCAM-1+ single sorted cells from two BM samples were analysed for their cumulative production of cells. A marked variation in proliferative capacity between individual BMSSCs is evident. The majority of clones (29/35, 83%) exhibited only moderate growth potential, which did not persist beyond 20 population doublings. 6/35 clones (17%) demonstrated continued growth extending beyond 20 population doublings.





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