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Fig. 9. Schematic model illustrating N-RAP scaffolding during assembly of the I-Z-I complex. (1) N-RAP binds to a membrane-associated complex containing integral membrane and linker components. (2) {alpha}-actinin is recruited to the complex. (3) Actin polymerizes along the N-RAP super repeats, with the barbed end of the actin filament integrating with {alpha}-actinin at the Z-body. The orientation of the actin filament is indicated by an arrowhead at the pointed end. (4) The premyofibril I-Z-I complex is released from the membrane, and N-RAP dissociates as the Z-bodies fuse laterally to form mature Z-lines. Krp1 is hypothesized to play a role in N-RAP dissociation from the nascent myofibril.





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