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Fig. 3. PDZ-domain-containing proteins at TJs associated with JAMs. Four TJ-associated peripheral membrane proteins, ZO-1, AF-6, PAR-3 and MUPP1, directly bind to JAM-A. ZO-1 and PAR-3 associate also with JAM-B and JAM-C. In all cases, the associations are mediated through PDZ-domain-dependent interactions. Note that the PDZ domain(s) of ZO-1 interacting with JAM-B and JAM-C have not yet been determined.





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