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Fig. 4. The PAR-3-aPKC-PAR-6 complex is associated with JAMs through PAR-3. PAR-3 binds directly to JAM-A, JAM-B and JAM-C through its first PDZ domain. Atypical PKC (aPKC) links PAR-3 with PAR-6. The binding of active Cdc42 to the CRIB domain of PAR-6 results in aPKC activation, possibly through a Cdc42-induced conformational change of PAR-6. A direct association between PAR-3 and PAR-6 in vitro, mediated through the PDZ domain 1 of PAR-3 and the PDZ domain of PAR-6, has also been reported (Lin et al., 2000).





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