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Fig. 7. Cell-cell contact targeting may be controlled through the PKC ${alpha}$ C2-V3 region. (A) although the deletion of the V1 domain abolishes PKC ${alpha}$ translocation, the selective targeting to cell-cell contacts is restored in the absence of both V1 and the pseudosubstrate domain. Thus, the PKC ${alpha}$ N terminus including the V1 and the pseudosubstrate domains is not required for PKC targeting to cell-cell contacts. (B) A further deletion of the catalytic domain does not affect the targeting to cell-cell contacts. A comparison of the (C1-V3)-GFP and the (C1+V3)-GFP (see Fig. 6A) subcellular locations suggests that the C2 region may also be required for the selectivity of targeting to cell-cell contacts.

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