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Fig. 3. Analysis of CFTR channel activity in the presence of different syntaxins. (A) Expression profile analysis of different syntaxins before (NT) or after plasmid transfection in CHO-CFTR cells (Syn8{Delta}TM, Syn1A and Syn3). Bars, 20 µm. (B) Summary of data collected from four independent iodide efflux experiments using CHO-CFTR cells (empty columns) or CHO+CFTR+Syn8{Delta}TM clone (filled columns). (C) Summary of data obtained from 12-16 independent iodide efflux experiments using CHO-CFTR, CHO-CFTR+Syn3 and CHO-CFTR+Syn1A stimulated by 5 µM forskolin. Data are expressed as a percentage of CFTR maximal activity. ***P<0.0001; ns, not significant.





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