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Fig. 9. The Rab5a(S34N) dominant negative mutant inhibits axonal trafficking and presynaptic clustering of VGAT. Confocal images of hippocampal neurons transfected with plasmids encoding VGAT-HA and GFP-tagged Rab5a(S34N). Neurons were double immunolabeled for HA and GFP. (A) A view of the soma reveals that VGAT-HA colocalizes with GFP-Rab5a(S34N) in the Golgi compartment. (B) A view of a neuron expressing VGAT-HA and GFP-Rab5a(S34N). The red color was enhanced to show the axon. VGAT shows a weak diffuse staining in axons and is not detected in presynaptic clusters in the proximal (enlarged frame a) or in the distal axon (enlarged frame b). Scale bars, 10 µm.





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