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Fig. 5. Effect of type 3 RyR knockdown or RyR inhibition on global Ca2+ signaling upon activation of the Ins(1,4,5)P3/Ca2+-signaling system. T cells [control clone E2 (a) or type 3 RyR-knockdown clone 25 (b), or Jurkat T cells (c,d)] were loaded with Fura-2/AM and analyzed by single-cell Ca2+ imaging as described in the Materials and Methods. Ins(1,4,5)P3 was microinjected (pipette concentration 4 µM) as indicated. Ruthenium Red (RuRed; pipette concentration 10 µM) was co-injected together with Ins(1,4,5)P3. Data acquisition rate was 0.75 ratios/second. Characteristic tracings out of 5-9 cells are displayed.





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