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First published online May 4, 2004

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CRM1 and IFN-1 mRNA: nuclear export partners

In general, the nuclear import and export of proteins and nucleic acids requires transport receptors known collectively as karyopherins. However, nuclear export of most mRNAs is mediated by the non-karyopherin mRNA receptor TAP. Now, on p. 2259, Jun-Ichi Fujisawa and colleagues report that the nuclear export of interferon-1 (IFN-1) mRNA is mediated by CRM1, a karyopherin more often involved in the export of proteins (including the HIV-1 Rev protein), U-rich small nuclear RNAs, and rRNAs. The authors show that the nuclear export of IFN-1 mRNA is inhibited by overexpression of Rev, provided the protein carries an intact nuclear export signal, and by two inhibitors of CRM1 function. In addition, IFN-1 mRNA colocalizes with CRM1 but not TAP in the nucleus. Surprisingly, the adenylate/uridylate-rich element (ARE) in the 3' untranslated region of IFN-1 mRNA is not required for its nuclear export; in other mRNAs whose export is CRM1 dependent, the RNA adaptor HuR mediates export by binding to the ARE. Thus, a new RNA adaptor may be required for CRM-1-dependent nuclear export of IFN-1 mRNA.

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Related articles in JCS:

CRM1-dependent, but not ARE-mediated, nuclear export of IFN-1 mRNA

Tominori Kimura, Iwao Hashimoto, Takahiro Nagase, and Jun-Ichi Fujisawa
JCS 2004 117: 2259-2270. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?