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Fig. 1. Genomic organization of the SLMAP gene. (A) The SLMAP gene is composed of 24 exons and introns spanning over 122 kb of genomic DNA. Exon-exon (exons I-XXIV) boundaries are depicted. Exons XI (red), XII (black), XIII (blue), XVII (orange) and XXIII (green) encode alternative exons. Transmembrane domains are encoded by exon XXIII and exon XXIV. Exon XX and exon XXI contain the leucine zipper motifs (*). ATG1 (M1, red arrow) is encoded in exon I, whereas ATG2 (M2; green arrow) is present in exon II. (B) Amino acid composition of alternative exons XI, XII and XIII. Consensus casein kinase 2 phosphorylation sites are underlined; protein kinase C phosphorylation sites are indicated in blue; N-glycosylation site is in italics; and the N-myristolyation site is shown in red.





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