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Fig. 11. Ultrastructural changes of the stratum corneum and the transition of stratum granulosum to stratum corneum in CTSD(–/–) mice. Electron microscopy shows that in wild-type mice (A) the cornified envelope (CE) is clearly visible as dark lines around the corneocytes (arrow). In CTSD(–/–) mice (B) there is a broadening of the intercellular spaces in the stratum corneum (SC), only a faint staining of the CE (arrow) and the corneocytes are thickened in the axial direction. SG, stratum granulosum.





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