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Fig. 5. Loss of ultrastructural elements of the BM zone caused by L{gamma}f. At 14 days untreated 3D-cocultures (A,C) reveal a mostly continuous BM (arrows indicate the lamina densa) and regularly structured hemidesmosomes (arrowheads in C; detailed view) linked to prominent keratin filament bundles (kf). Treatment with L{gamma}f not only prevents assembly of BM, but also of hemidesmosomes (B,D) and the association of keratin filaments (kf). Basal cells seem to attach frequently to type I collagen fibrils which can be seen in cross and longitudinal section (D; some contacts are indicated by short arrows). e, epithelium; m, matrix. Scale bars: 250 (A,B) and 100 nm (C,D).





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