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Fig. 6. Persistence of adhesion molecules in 3D-cocultures at 14 (A-D), 19 (E,F) and 21 days (G-K). The patterns of controls (left column) generally undergo only minor changes in the presence of Lf (right column) as demonstrated for the integrin chains 2 (A,B), 3 (C,D), v (E,F), 6 (G,H), and bullous pemphigoid antigen 2 (I,K; BPAG2/BP180). In treated samples, 2 (B) is slightly stronger in basal cells, while the distribution of 3 (D) appears slightly more pericellular and v (F) is less polarised. Further the prominent co-localisation of 6 and BPAG2 in controls (G,I) is not maintained upon treatment with Lf (H,K), indicating extensive shedding of 6 (H) and a mostly pericellular label of basal cells with BPAG2 (K). Arrowheads in D,F,K indicate the partially labelled surface of the collagen matrix in split areas. Scale bars: 50 µm.

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