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Fig. 4. An intact NLS in p120^ctn is integral for p120^ctn nuclear localization and the p120^ctn-induced branching phenotype. (A) Expression of wild-type eGFP-fused p120^ctn (p120^ctn-WT) causes the characteristic branching phenotype in NIH 3T3 cells (Ai) and HeLa cells (Bi). Expression of NLS-defective p120^ctn (p120^ctn-NLSmut) is largely restricted to the cytosol and unable to induce the branching phenotype (Aii and Bii). (C) An 18 hour LMB treatment caused the nuclear retention of both p120^ctn-WT (Cii) and p120^ctn-NLSmut (Dii). Results are indicative of at least 100 cells observed for each construct. Bars, 10 µm.

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