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Fig. 1. Eye phenotypes caused by misexpression of the RacGAP(84C) protein or its GAP domain. (A,C,E,G,H) External aspects viewed with a dissecting microscope. (B,D,F) Semi-thin tangential histological sections. (A,B) GMRGal4/UAS-lacZ control flies. (A) Eyes exhibit a regular array of about 800 repeated ommatidia. (B) Normal ommatidial architecture characterised by a trapezoidal array of outer photoreceptor cells R1-6 and central R7 cell, surrounded by accessory cells. (C,D) GMRGal4/UAS-RacGAP(84C). (C) Eye-directed expression of RacGAP(84C) induces rough eyes with black patch in the anterior-most part. (D) RacGAP(84C)-expressing retina shows a reduced number of randomly dispersed ommatidia and vacuolated material (arrows) associated with abnormal numbers of photoreceptor cells and misshapen rhabdomeres (arrowheads). (E,F) GMRGal4/UAS-Rac1N17. (E) Eye-directed expression of Rac1N17 induces rough eyes. (F) Rac1N17-expressing retina shows loss of rhabdomeres (open arrowhead), abnormal photoreceptor cells (black arrowheads), vacuolated material (arrows), and polarity defects (bar). (G) GMRGal4/+; UAS-GAP17/+ eye expressing the isolated GAP domain of RacGAP(84C) (weak strain). (H) Eye-directed expression of RasN17 induces reduced and rough eyes (RasN17/Y; GMRGal4/+).





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