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Fig. 5. Local application of mannitol, an ionic control for 2-DG, suggests that inhibition of transport by 2-DG is not due to inhibition of glycolysis. (A) Kymograph of distribution and movements of Mitotracker-labeled mitochondria. The position and time of drug application (200 mM mannitol and Lucifer Yellow in DMEM) is shown in blue. (B) Hand-drawn traces of anterograde (blue) and retrograde (red) mediated movements used to quantify the mitochondrial transport. (C-F) Normalized anterograde and retrograde transport. Error bars are the normalized 95% confidence intervals (n=5 experiments). (D-E) After 5 minutes of drug application, both anterograde and retrograde transport are significantly (P<0.05) decreased for each direction of transport past the point of drug application. (F) Anterograde and retrograde transport increase after drug application is stopped.





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