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Fig. 2. Caffeine reversibly suppresses [Ca2+]i oscillations in ICCs. Panels A1 to 3 show [Ca2+]i images recorded at lines (1) to (3) in B, respectively. Horizontal bar=100 µm. Traces in B indicate the time course of the changes in [Ca2+]i (Ft/F0) in the square regions indicated in A(1): blue line for (x) and red line for (y). After observing control [Ca2+]i oscillations in the presence of 2 µM nifedipine (Ba), 10 mM caffeine was applied. Bb and Bc were recorded after 3 minutes and 5 minutes, respectively. Bd shows recovery of [Ca2+]i oscillations 5 minutes after washout of caffeine in the presence of nifedipine. In C and D, after observing control [Ca2+]i oscillations (a), effects of 30 µM tetracaine and 10 µM FK506 were examined, respectively. The trace Cb was recorded 5 minutes after tetracaine application, while Db was 2 minutes after FK506 application.





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