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Fig. 6. Analyses of xenografted tumours induced by MDCK-Snail and MCDK-E47 cells. (A) Growth behaviour of MDCK-CMV, MDCK-Snail and MDCK-E47 cells after injection in nude mice. (B) Proliferation of the three cell types in two-dimensional cultures. (C) Tumours induced into nude mice by MDCK-Snail (Snail) (a-e) and MDCK-E47 (E47) (f-j) cells were analysed by histology (a,f); immunostaining for E-cadherin (b,g); and in situ hybridization for E-cadherin (c,h), Snail (d,i) and E47 (e,j) transcripts. Note the absence of E-cadherin (c) and focal expression of E47 (e) transcripts in MDCK-Snail induced tumours; and the more heterogeneous expression of E-cadherin (h) and E47 (j) transcripts, but complete absence of E-cadherin protein (g) in MDCK-E47 induced tumours. Inset in b shows E-cadherin staining in the epidermis adjacent to the tumour. Cryostat sections were used for the histological and immunofluorescence analyses; vibratome sections were used in the ISH analyses. Bars, 50 µm.





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