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Fig. 2. NHERF binding to ßPDGFR is not essential for PDGF-mediated actin cytoskeletal reorganization. PDGF-BB stimulation (5 ng/ml for 10 minutes) of F cells expressing WT or the mutant L1106A results in the aggregation of F-actin at the cell periphery (arrows), dorsal ruffles (arrowheads), filopodia formation and diminution of actin stress fibers. Scale bars, 10 µm.





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