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Fig. 6. P35 expression inhibits NO-mediated PARP cleavage in RAW 264.7 cells. RAW 264.7 cells or vector- or p35-transfected clones were treated with cisplatin (2 µg/ml) and IFN-{gamma} (25 U/ml) or LPS (1 µg/ml) and IFN-{gamma} (25 U/ml) in the presence or absence of LNMMA (1 mM) as before. Cells were also treated directly with NO donor, SNP (1 mM). After 36 hours of treatment, cell extracts were analyzed by immunoblotting with anti-PARP antibody to assess cleavage of PARP.





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