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Fig. 7. Model for P35-mediated inhibition of NO-induced apoptosis in activated macrophages. Mitochondrial cytochrome c release is a critical event in molecular pathway of apoptosis that triggers subsequent caspases activation and apoptotic cell death. Baculovirus protein P35 inhibits mitochondrial cytochrome c release as well as caspase activation. This also raises the possibility that activation of caspases may be the cause rather than consequence of cytochrome c release. AIF, apoptosis inducing factor; Apaf-1, apoptotic protease activating factor-1.





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