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Fig. 2. The NE is a Ca²⁺ store that allows access of ions to the cytoplasm through the NPCs [modified figure reproduced with permission from Elsevier (Gerasimenko et al., 1995)]. (A) Nucleus loaded with Fura 2 in the acetoxymethyl (AM) ester form. Only NE is loaded with Ca²⁺ dye. (B) Nucleus is loaded with Calcium Green dextran, accumulated in the nucleoplasm. (C) Model of Ca²⁺ store in the NE. The NE is freely accessible to ions through NPCs and can release Ca²⁺ directly into nucleoplasm. cADPR, cyclic ADP-ribose; INM, inner nuclear membrane; IP₃, inositol (1,4,5)-trisphosphate; ONM, outer nuclear membrane. Bars, 5 µm.

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