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Fig. 8. Endothelial cells treated with DP siRNA are able to send out cellular projections. (A) Wild-type HMEC-1 cells send out filopodia (arrow) within 2-3 hours of plating onto matrigel. (B) Arrowhead and arrow point to filopodia from adjacent cells coming in close contact with each other. The arrowhead points to a filopodia extending from the middle cell, while the top arrow points to a filopodia extending from the top cell towards the middle cell filopodia. (C) Low-magnification view of cells treated with DP siRNA. Arrows point to long filopodia. (D) Higher magnification of cells in C show at least two filopodia. Arrows point to a filopodia extending from the lower left cell, while arrowheads point to a filopodia extending from the upper right cell. Bar, 10 µm (A, B, D); 25 µm (C).





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