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Fig. 10. Rac1 regulates FGF2 endocytosis. The effect of transient expression of Rac1 dominant negative (Rac1 DN-eGFP, A) and constitutively active (Rac1 CA-eGFP, B) constructs on FGF2 endocytosis was examined in RFPEC treated with fluorescently labeled FGF2 (red). Note decreased FGF2 uptake in cells expressing Rac1 DN-eGFP and increased uptake in cells expressing Rac1 CA-eGFP. Scale bars, 10 µm.





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