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Fig. 5. Single confocal sections of whole mount preparations of embryonic mouse hearts labelled with antibodies against different sarcomeric proteins (B,E,H,K; red in overlay A,D,G,J) and against phosphorylated histone H3 together with antibodies against beta-catenin to delineate the cell-cell contacts (C,F,I,L; green in overlay). Also in dividing cardiomyocytes in the heart in situ, ${alpha}$ -actinin (A,B) and titin T12 (D,E), which are Z-disk associated proteins/epitopes, are diffuse at a time when the localization pattern of myomesin (G,H) remains still quite intact (arrowheads delineate the cell borders, small arrows point at intact myofibrils in neighboring cardiomyocytes (D,E; J,K) or in dividing cells (G,H). The staining for titin T51 (J,K), which is an M-band associated titin epitope, becomes diffuse only by anaphase, similar to myomesin (data not shown). Continuous staining for beta-catenin along the plasma membrane also in dividing cardiomyocytes indicates that cardiomyocytes retain their contacts to the neighboring cells during division. Bar represents 10 µm.

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