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Fig. 1. Location of ACTA1 mutations on the three-dimensional representation of the actin molecule. The 19 mutations selected for this study, encompassing 17 residues, are located on the four subdomains of the actin molecule (labeled I-IV). They lead to different severities of disease. The structure was taken from PDB code 1ATN and displayed by NetViewerLite (Accessory Software).





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