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Fig. 1. NRF domains and DNA fragments used in the study (A) Amino acid sequence of human NRF as deduced from the cDNA clone used in this study. Asterisk indicates the stop codon. (B) Schematic illustration of the NRF protein showing the NLS, the NF-{kappa}B repression domain, the DNA binding domain (DBD) and consensus sequence motifs for RNA binding (JAG), nucleic acid binding (G-Patch) and single-stranded nucleic acid binding (R3H). Several dsRNA binding motifs are found between amino acid (aa) 349 and aa 512 (dashed line). (C) Schematic representation of the full-length NRF tagged with His-Myc epitope or with GFP and NRF deletion mutants fused to GFP. The His-Myc-tag was fused in-frame to the amino terminus of NRF, while GFP was added in-frame to its C-terminal end.





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