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Fig. 8. Functional domains important for localization and splicing activity of chicken ETR-3. Deletion and gain-of-function analyses revealed an NLS within the last 20 amino acids at the C terminus and CRM1-dependent nuclear export activity within the divergent domain. A second region involved in nuclear localization in the last 53 amino acids of the divergent domain (dotted line) was identified by deletional analysis. Regions within the first two RRMs were also identified by deletional analysis that are important for cytoplasmic localization, though this is perhaps due to the RNA binding capacity of these domains. The first quadrant of the divergent domain and the C terminus were also found to be important for splicing activation by ETR-3 independent of its localization to the nuclear compartment.
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